When I was a young doctor, I had a patient with zero-negative Rheumatoid Arthritis – i.e., she was experiencing rheumatic pains but showed no rheumatoid factors in the blood test. All my naturopathic knowledge did not bring any relief to this patient.
Speaking to an older colleague, I mentioned that the patient had surgically removed skin cancer, and they replied: “So, she is probably avoiding the sun…have you checked her Vitamin D3?”. As it turns out, she was very deficient, and substitution soon relieved her rheumatoid symptoms.
History: Vitamin D Supplements
Rickets (soft bones in children) was described by doctors in the 18th century. In the 1920s, it was attributed to Vitamin D. Nowadays, through Vitamin D supplementation and fortification, rickets has pretty much disappeared from the developed world. We now know that Vitamin D is responsible for a lot more than bone health.
The Vitamin D Receptor (VDR)
Vitamin D not only supports our bone health but our skin, immune system, metabolism, and even our ageing processes. At the core of this mechanism is the Vitamin D receptor – one of the 49 nuclear receptors in each of our cells. In short, the VDR controls how Vitamin D works inside our cells.
Most of us are familiar with the fact that Vitamin D activates this receptor. But scientists have discovered something new: compounds that can dial down the receptor’s activity instead. That is, not just activate but down-regulate, too. These compounds are called inverse agonists. One of the most promising of these is Metadichol® (the key ingredient in NANO SOMA®), a nanolipid formulation that fine-tunes how the VDR behaves.
Why the VDR Matters
The VDR controls many key processes in your body:
- Bone health through calcium balance
- Immune regulation and a healthy inflammatory response
- Skin health by guiding skin tissue repair
- Muscle function
- Cell growth and differentiation
- Blood sugar regulation
- Liver health
Traditional approaches that activate the VDR (like Vitamin D analogues) can be useful but risky – they may cause high calcium levels in the blood (hypercalcemia).
That’s where inverse agonists like Metadichol come in, offering a natural way to help rebalance VDR activity without those side effects.*
How Metadichol Works with the VDR
Instead of simply switching the VDR “on,” Metadichol prompts the body to adjust its baseline activity. Thus, the body can either reduce or shift the VDR’s signaling, depending on the situation and what’s needed. This flexible behaviour is called protean agonism—think of it as a “smart regulator” rather than just an on/off switch.
Key findings so far:
- Patents and research confirm Metadichol binds strongly to the VDR and works as an inverse agonist.
- Protean action means it can adapt to different states of the receptor, offering more balanced control.
- Clinical interest is growing, especially in skin and immune-related conditions.
Benefits Seen in Research
- Skin Health and Inflammatory Response
- Psoriasis, eczema, acne: These issues involve overactive immune pathways (like Th1/Th17 and TNF-α). Metadichol’s ability to help the body calm these pathways may support the body’s healthy inflammatory response* and promote skin balance.*
- Barrier repair: By modulating the VDR instead of overstimulating it, Metadichol may support healthier skin* without the side effects of ingesting high quantities of Vitamin D.
- Immune Balance Without Overreaction
- In lab studies, Metadichol boosted Vitamin D binding protein (VDBP) – a key factor that strengthens our innate immunity.*
- It also helped immune cells respond to inflammation without overreacting. This could mean the body’s natural defence mechanisms against infections are strengthened,* while simultaneously avoiding damaging hyperinflammation.
- Systemic and Metabolic Effects
Although much research focuses on skin, the VDR is found throughout the body:
- Metabolism: By influencing the VDR in fat, pancreas, and immune cells, Metadichol may help promote healthy glucose balance and insulin sensitivity* (still early evidence).
- Thyroid and hormones: Some reports suggest that Metadichol can help support a healthy thyroid* and promote natural hormonal balance.*
- Anti-ageing potential: Metadichol can also prompt the body to influence genes linked to longevity, cell repair, and resilience, possibly adding anti-ageing benefits.*
Conclusion
Metadichol offers a new way to influence the Vitamin D receptor—not by fully switching it on, but by prompting the body to gently rebalance its activity.* This unique approach may:
- Help promote healthy skin*
- Strengthen immunity without overactivity*, and
- Support metabolism, hormone balance, and even healthy ageing.*
As the research continues, Metadichol may prove to be a groundbreaking tool for fine-tuning how Vitamin D works in the body.
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*These statements have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose or prescribe for any medical condition, nor to prevent, treat, mitigate, or cure such condition(s). If you have any illness or medical condition, consult your healthcare provider.